And there is Smashwords, which will take your manuscript, chew it up, and spit out files that can be made available to all the big e-pub catalogs -- Amazon, B&N, Stanza, iPad, and, apparently even as POD on Lulu.com. I love it that their convertor is called MeatGrinder ...
I've been dabbling with this kind of stuff a bit, as you can see from the PDFs for sale here and the links to Amazon.com for Kindle titles.
I'm thinking maybe one of my current projects might be one I could use to take a wider shot at this market. My agent isn't thrilled with my old retired spy novel, I'm not going to rewrite to her direction, and maybe it might be one that could go viral out there in the land of electronica.
Never know until you try.
You have to generate covers for ebooks, at least in some venues, and I've done a couple I thought worked well enough -- Master of Pamor, The Digital Effect. With a few minutes and a camera that shoots to a flashmem card, you can create one easily enough. Cover doesn't have to have anything to do with the contents, I've learned, long as it looks interesting.
I think this one above might catch a certain essence of my novel.
I'm thinkin' hard about this ...